We've all done it - we've reached up to hit the Escape key in AutoCAD - only to find ourselves staring at the AutoCAD Help screen! Aaaaaargh! How did that happen? Well we were reaching for the Escape key - and that pesky F1 key got in the way.
via lynn.blogs.com
This is a very common request to change the behaviour of the F1 key to an escape instead of Help.